The Aesthetic Guide is part of the Informa Markets Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

Harnessing the Power of Platelet-Derived Exosomes in Topical Skincare

Article-Harnessing the Power of Platelet-Derived Exosomes in Topical Skincare

Sponsored By Rion Aesthetics; As more patients seek science-backed, noninvasive aesthetic treatments, exosomes have rapidly emerged as a treatment for skin rejuvenation.

Sponsored By Rion Aesthetics;

As more patients seek science-backed, noninvasive aesthetic treatments, exosomes have rapidly emerged as a treatment for skin rejuvenation. Studies by Rion Aesthetics (Rochester, Minn.) have shown the effectiveness of platelet-derived exosomes for skin renewal, leading to the creation of Renewosome technology, the proprietary ingredient in their ( plated )™ Skin Science products.


Rion Aesthetics is a regenerative aesthetics company that has been pioneering the use of platelet-derived exosome technology with the launch of investigational studies in both hair restoration and facial wrinkles. The company’s flagship product, ( plated ) INTENSE serum, has highly robust clinical data and is ideal for rejuvenating the appearance of moderate to severe photodamaged skin. The company’s other products: ( plated ) CALM serum has shown benefits post-procedure to accelerate skin recovery and ( plated ) DAILY serum is designed to prevent the appearance of mild photodamaged skin.

According to board-certified plastic surgeon Louis Bucky, MD (Philadelphia, Penn.), platelets act as a first responder. “Simply put, when it comes to skin rejuvenation, nothing works like platelet-derived exosomes,” he reported. “The process that Rion Aesthetics uses to obtain platelet exosomes is cutting-edge and unique in the industry. It is pure and consistent, especially when compared to other cellularderived exosomes.

“My patients have started seeing results quickly using ( plated ) on a daily basis,” Dr. Bucky continued. “The INTENSE serum is our most popular seller as it has the highest concentration of Renewosome technology. A small amount daily produces powerful results. My patients have reported a noticeable improvement with their skin tone and texture, while diminishing the visible signs of aging.”

Dr. Bucky explained that after spending 15 years studying stem cells, Rion Aesthetics’ founding physician-scientists discovered that platelets, not stem cells, held the key to the rejuvenation of the skin’s appearance. “They developed a way to harness the power of platelet-derived exosome technology,” he shared. “This proprietary exosome manufacturing process results in a room temperature, shelf stable formulation that is consistent across every batch and sourced responsibly from FDA inspected sites.”

Saranya Wyles, MD, PhD, a dermatologist in Rochester, Minn., reported that platelet-derived exosomes have regenerative appearance effects that are controlled by biomolecules including ingredients derived from growth factors, cytokines and exosomes that are released from the platelets. “Platelet exosomes also have a biomanufacturing advantage, meaning that exosomes can be isolated from pooled platelets at the time of collection,” she clarified.


Dr. Wyles emphasized that when it comes to aesthetic applications, exosome source matters. Platelet-derived exosomes harbor the greatest potential for regeneration of skin appearance without concern for phenotypic alteration during the biomanufacturing process as seen in stem cell-based exosome sources. “Patients who were enrolled in the clinical study evaluating platelet-derived Renewosome technology, specifically the ( plated ) INTENSE serum, appreciated improvement in the appearance of redness, brown spots, color evenness, luminosity and wrinkle reduction, lasting six months with daily product use,” she explained.

Topical skincare has become a significant addition to many aesthetic treatments to speedily improve the appearance of healing skin, lessen downtime and improve results and Rion Aesthetics seems to be leading the way. As Dr. Bucky succinctly added, “There is no other brand that I am aware of that has bottled the power of platelets in a shelf stable, topical product. It is truly revolutionary.”

Hide comments


  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.